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2-Butyl-4-chloro-5-formylimidazole

Product Name: 2-Butyl-4-chloro-5-formylimidazole
CasNo: 83857-96-9
Purity:
Appearance: Yellow solid

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CasNo： 83857-96-9

Molecular Formula： C₈H₁₁ClN₂O

Appearance： Yellow solid

Reputable Factory Supply High Purity 83857-96-9 2-Butyl-4-chloro-5-formylimidazole with Efficient Transportation

Molecular Formula:C8H11ClN2O
Molecular Weight:186.641
Appearance/Colour:Yellow solid
Vapor Pressure:0.001Pa at 25℃
Melting Point:97-100 °C(lit.)
Boiling Point:384.1 °C at 760 mmHg
PKA:8.87±0.10(Predicted)
Flash Point:186.1 °C
PSA：45.75000
Density:1.24 g/cm³
LogP:2.21820

2-Butyl-4-chloro-5-formylimidazole(Cas 83857-96-9) Usage

Description	2-Butyl-4-chloro-5-formylimidazole is a biochemical reagent that can be used for life science research. It is also an API intermediate used in the manufacturing of a range of APIs and advanced intermediates. For example, it is used as an intermediate for the anti-hypertensive drug Chlosartan.
Uses	2-Butyl-4-chloro-5-formylimidazole is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists

InChI:InChI=1/C8H11ClN2O/c1-2-3-4-7-10-6(5-12)8(9)11-7/h5H,2-4H2,1H3,(H,10,11)

83857-96-9 Relevant articles

Iodine as a chemoselective reoxidant of TEMPO: application to the oxidation of alcohols to aldehydes and ketones.

Miller, Ross A,Hoerrner, R Scott

, p. 285 - 287 (2003)

[reaction: see text] Chemoselective alco...

Synthesis, DFT calculations and biological activity of a new Schiff base of 4-aminoantipyrine and its Co(II), Ni(II), Cu(II) and Zn(II) complexes and crystal structure of the Schiff base

Ajmeera Ramesh, Ravider Pawar, Perugu Shyam & Allikayala Ramachandraiah

Research on Chemical Intermediates, Volume 47, pages 4673–4697, (2021)

A novel Schiff base, (Z)-4-(((2-butyl-4-chloro-1H-imidazol-5-yl)methylene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one, labelled as 4AAP-BCFI, is synthesized by adduction of 4-aminoantipyrene with 2-butyl-4-chloro-5-formylimidazole, and its molecular structure has been determined by a single-crystal X-ray diffraction studies. The cationic complexes of the 4AAP-BCFI with Co(II), Ni(II), Cu(II) and Zn(II) metal ions are also synthesized and characterized.

Method for recovering and utilizing byproduct of chlorination of phosphorus pentachloride

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Paragraph 0038-0039, (2017/08/28)

The invention relates to a technology fo...

83857-96-9 Process route

: (1-iminopentyl)glycine tert-butyl ester

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 83857-96-9
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde

Conditions

Conditions	Yield
(1-iminopentyl)glycine tert-butyl ester; With trifluoroacetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 24h; Large scale; With trichlorophosphate; In toluene; at 80 ℃; for 2h; Large scale; N,N-dimethyl-formamide; In toluene; at 105 ℃; for 7h; Temperature; Large scale;	89.2%

(NH₄)2 Ce(NO₃)6: (NH₄)2 Ce(NO₃)6

: 75-09-2
dichloromethane

: 79047-41-9
2-n-butyl-4-chloro-5-hydroxymethylimidazole

: 83857-96-9
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde

Conditions

Conditions	Yield
With potassium hydroxide; In water; acetic acid;	92%
In water; acetic acid;

83857-96-9 Upstream products

79047-41-9
2-n-butyl-4-chloro-5-hydroxymethylimidazole
139742-78-2
4⁽⁵⁾-bromo-2-butyl-1H-imidazole-5⁽⁴⁾-carboxaldehyde
68282-49-5
2-butyl-1H-imidazole-5-carboxaldehyde
68-12-2
N,N-dimethyl-formamide

83857-96-9 Downstream products

133040-02-5
2-butyl-4-chloro-1-<(4-carbomethoxyphenyl)methyl>-1H-imidazole-5-carboxaldehyde
141692-01-5
3-benzyl-2-butyl-5-chloro-3H-imidazole-4-carbaldehyde
114772-66-6
2-butyl-4-chloro-5-formyl-1-[(2'-methoxycarbonyl-1,1'-biphenyl-4-yl)methyl]-1H-imidazole
133909-85-0
2-butyl-4-chloro-1-<<2'-(5-fluoro-1,2,3-triazol-4-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde

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