Trustworthy Factory Supply 765-30-0 with Safe Shipping, Buy Quality Cyclopropylamine
- Molecular Formula:C3H7N
- Molecular Weight:57.0953
- Appearance/Colour:Clear and colourless, volatile liquid
- Vapor Pressure:4.67 psi ( 20 °C)
- Melting Point:-50 °C
- Refractive Index:1.4206
- Boiling Point:49.3 °C at 760 mmHg
- PKA:pK1:9.10(+1) (25°C)
- Flash Point:-14 °F
- PSA：26.02000
- Density:0.938 g/cm3
- LogP:0.80780
Cyclopropylamine(Cas 765-30-0) Usage
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Chemical Properties
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Cyclopropylamine (CPA) is a primary aliphatic amine with the formula C3H7N. It's a mouse metabolite and an essential intermediate in the preparation of many biologically active substances. It is a colorless and transparent flammable liquid with volatility and ammonia odor. It is miscible with water, methanol, ethanol, benzene, toluene and other solvents.
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Uses
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Cyclopropylamine is mainly used in organic synthesis and pharmaceutical synthesis intermediates. It can be used in the synthesis of new antibacterial drugs such as ciprofloxacin, enrofloxacin, and spafloxacin. Cyclopropylamine is a primary aliphatic amine that consists of cyclopropane bearing a single amino substituent. It has a role as a mouse metabolite. |
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Biochem/physiol Actions
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Cyclopropylamine inactivates cytochrome P450 enzymes by a mechanism involving initial one-electron oxidation at nitrogen followed by scission of the cyclopropane ring leading to covalent modification of the enzyme. It is a mechanism-based inhibitor of quinoprotein methylamine dehydrogenase from Paracoccus denitrificans.
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Purification Methods
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It has been isolated as the benzamide m 100.6-101.0o (from aqueous EtOH). It forms a picrate m 149o (from EtOH/pet ether) from which the free base can be recovered using a basic ion-exchange resin and can then be distilled through a Todd column (p 11) using an automatic still head which only collects products boiling below 51o/atm. Polymeric materials if present will boil above this temperature. The hydrochloride has m 85-86o [Roberts & Chambers J Am Chem Soc 73 5030 1951, Jones J Org Chem 9 484 1944, Emmons J Am Chem Soc 79 6522 1957]. [Beilstein 12 IV 3.]
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InChI:InChI=1/C3H7N/c4-3-1-2-3/h3H,1-2,4H2
765-30-0 Relevant articles
The Insertion Reaction of NH Singlet Radicals into the C-H Bonds of Cyclopropane and Isobutane in the Liquid Phase
Hamada, Jun-ich,Tsunashima, Shigeru,Sato, Shin
, p. 1739 - 1742 (1982)
Hydrogen azide was photolyzed in liquid ...
Method for preparing amine through catalytic reduction of nitro compound by cyclic (alkyl) (amino) carbene chromium complex
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Paragraph 0015, (2021/04/17)
The cyclic (alkyl) (amino) carbene chrom...
Novel method and technology for synthesizing cyclopropyl ammonia
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Paragraph 0019, (2021/09/21)
The invention discloses a synthesis proc...
O -Phthalaldehyde catalyzed hydrolysis of organophosphinic amides and other P(O)-NH containing compounds
Li, Bin-Jie,Simard, Ryan D.,Beauchemin, André M.
supporting information, p. 8667 - 8670 (2017/08/10)
Over 50 years ago, Jencks and Gilchrist ...
NHC-based coordination polymers as solid molecular catalysts for reductive amination of biomass levulinic acid
Sun, Zheming,Chen, Jiangbo,Tu, Tao
, p. 789 - 794 (2017/08/18)
A class of robust solid molecular NHC-ba...
765-30-0 Process route
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- 13324-66-8
N-benzylcyclopropanamine
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- 765-30-0
Cyclopropylamine
Conditions
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Yield |
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With mitochondrial monoamine oxidase; In water; Mechanism; Product distribution; experiments with 14C- and 3H-labelled compounds; comparison of enzyme and electrochemical amine oxidation mechanism (two electron transfers via a radical cation intermediate);
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- 3187-77-7
N-benzylidenecyclopropylamine
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- 765-30-0
Cyclopropylamine
Conditions
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Yield |
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With 20 μM Tris pH 9.0 buffer; at 25 ℃; Rate constant;
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765-30-0 Upstream products
765-30-0 Downstream products
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1453-50-5
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15205-35-3
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13140-86-8
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77991-97-0
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English
