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trans-clomifene citrate

  • Product Name: trans-clomifene citrate
  • CasNo: 7599-79-3
  • Purity:
  • Appearance:

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CasNo: 7599-79-3

Molecular Formula: C26H28ClNO•C6H8O7

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  • Molecular Formula:C26H28ClNO•C6H8O7
  • Molecular Weight:598.093
  • Melting Point:143-145°C 
  • Boiling Point:509°Cat760mmHg 
  • Flash Point:261.6°C 
  • PSA:144.60000 
  • Density:g/cm3 
  • LogP:5.31410 

trans-clomifene citrate(Cas 7599-79-3) Usage

Description

Clomiphene citrate is an estrogen analog with both estrogenic and antiestrogenic effects that are dose-dependent.

Uses

Clomiphene citrate is a selective estrogen receptor modulator and may improve semen quality by stimulating hormone synthesis and spermatogenesis.

7599-79-3 Relevant articles

CLOMIPHENE SYNTHESIS USING A SINGLE SOLVENT

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Paragraph 0029, (2017/04/04)

The present invention provides a one-pot...

PROCESS FOR THE PREPARATION OF ENCLOMIPHENE CITRATE HAVING NEEDLE SHAPED CRYSTAL HABIT.

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Paragraph 00203-00205, (2017/12/28)

The present invention relates an improve...

PROCESS FOR THE PREPARATION OF CLOMIPHENE

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Paragraph 0149; 0150; 0151, (2016/06/28)

An improved process for the preparation ...

7599-79-3 Process route

ethanamine, 2-[4-[(1E)-2-chloro-1,2-diphenyl ethenyl]phenoxy]-N,N-diethyl-, (±)-1,1‘-binaphthyl-2,2’-diylhydrogenphosphate

ethanamine, 2-[4-[(1E)-2-chloro-1,2-diphenyl ethenyl]phenoxy]-N,N-diethyl-, (±)-1,1‘-binaphthyl-2,2’-diylhydrogenphosphate

citric acid
77-92-9,906507-37-7

citric acid

clomiphene citrate
7599-79-3

clomiphene citrate

Conditions
Conditions Yield
ethanamine, 2-[4-[(1E)-2-chloro-1,2-diphenyl ethenyl]phenoxy]-N,N-diethyl-, (±)-1,1‘-binaphthyl-2,2’-diylhydrogenphosphate; With sodium hydroxide; In water; toluene; at 20 ℃; for 2h;
citric acid; In acetone; at 0 - 50 ℃; for 2h;
97.07 g
ethanamine, 2-[4-[(1E)-2-chloro-1,2-diphenyl ethenyl]phenoxy]-N,N-diethyl-, (±)-1,1‘-binaphthyl-2,2’-diylhydrogenphosphate; With ammonia; In ethyl acetate;
citric acid; In ethanol; ethyl acetate; at 20 ℃; for 1h;
 
ethanamine, 2-[4-[(1E)-2-chloro-1,2-diphenyl ethenyl]phenoxy]-N,N-diethyl-, (±)-1,1‘-binaphthyl-2,2’-diylhydrogenphosphate; With ammonium hydroxide; In tert-butyl methyl ether; water; isopropyl alcohol; for 1h;
citric acid; In ethanol; water; at 60 - 65 ℃;
269 g
clomiphene
911-45-5,15690-55-8,15690-57-0

clomiphene

citric acid
77-92-9,906507-37-7

citric acid

clomiphene citrate
7599-79-3

clomiphene citrate

Conditions
Conditions Yield
In ethanol; water; at 65 ℃; Solvent;
20.2 g

7599-79-3 Upstream products

  • 77-92-9
    77-92-9

    citric acid

  • 50-41-9
    50-41-9

    clomifene citrate

  • 19957-52-9
    19957-52-9

    2-{4-(1,2-diphenylethenyl)phenoxy}-N,N-diethylethanamine hydrochloride

  • 73404-00-9
    73404-00-9

    1-{4-[2-(diethylamino)ethoxy]phenyl}-1,2-diphenylethanol

7599-79-3 Downstream products

  • 911-45-5
    911-45-5

    clomiphene

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