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CasNo: 7599-79-3
Molecular Formula: C26H28ClNO•C6H8O7
Description |
Clomiphene citrate is an estrogen analog with both estrogenic and antiestrogenic effects that are dose-dependent. |
Uses |
Clomiphene citrate is a selective estrogen receptor modulator and may improve semen quality by stimulating hormone synthesis and spermatogenesis. |
The present invention provides a one-pot...
The present invention relates an improve...
An improved process for the preparation ...
ethanamine, 2-[4-[(1E)-2-chloro-1,2-diphenyl ethenyl]phenoxy]-N,N-diethyl-, (±)-1,1‘-binaphthyl-2,2’-diylhydrogenphosphate
citric acid
clomiphene citrate
Conditions | Yield |
---|---|
ethanamine, 2-[4-[(1E)-2-chloro-1,2-diphenyl ethenyl]phenoxy]-N,N-diethyl-, (±)-1,1‘-binaphthyl-2,2’-diylhydrogenphosphate; With sodium hydroxide; In water; toluene; at 20 ℃; for 2h;
citric acid; In acetone; at 0 - 50 ℃; for 2h;
|
97.07 g |
ethanamine, 2-[4-[(1E)-2-chloro-1,2-diphenyl ethenyl]phenoxy]-N,N-diethyl-, (±)-1,1‘-binaphthyl-2,2’-diylhydrogenphosphate; With ammonia; In ethyl acetate;
citric acid; In ethanol; ethyl acetate; at 20 ℃; for 1h;
|
|
ethanamine, 2-[4-[(1E)-2-chloro-1,2-diphenyl ethenyl]phenoxy]-N,N-diethyl-, (±)-1,1‘-binaphthyl-2,2’-diylhydrogenphosphate; With ammonium hydroxide; In tert-butyl methyl ether; water; isopropyl alcohol; for 1h;
citric acid; In ethanol; water; at 60 - 65 ℃;
|
269 g |
clomiphene
citric acid
clomiphene citrate
Conditions | Yield |
---|---|
In ethanol; water; at 65 ℃; Solvent;
|
20.2 g |
citric acid
clomifene citrate
2-{4-(1,2-diphenylethenyl)phenoxy}-N,N-diethylethanamine hydrochloride
1-{4-[2-(diethylamino)ethoxy]phenyl}-1,2-diphenylethanol
clomiphene