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2-Thiopheneacetyl chloride

Product Name: 2-Thiopheneacetyl chloride
CasNo: 39098-97-0
Purity:
Appearance: clear brown liquid

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CasNo： 39098-97-0

Molecular Formula： C₆H₅ClOS

Appearance： clear brown liquid

Reputable Factory Supply 39098-97-0 with Reasonable Price, Buy Quality 2-Thiopheneacetyl chloride

Molecular Formula:C6H5ClOS
Molecular Weight:160.624
Appearance/Colour:clear brown liquid
Vapor Pressure:4 mm Hg ( 83 °C)
Refractive Index:n20/D 1.551(lit.)
Boiling Point:202.4 °C at 760 mmHg
Flash Point:88.7 °C
PSA：45.31000
Density:1.335 g/cm³
LogP:2.05600

2-Thiopheneacetyl chloride(Cas 39098-97-0) Usage

Description	2-Thiopheneacetyl chloride is used as a reagent to synthesize diamide derivatives of (S)-BINOL. These derivatives display potential anti-inflammatory and anti-arthritis effects. 2-Thiopheneacetyl chloride is also used in the synthesis of Nitrocefin (N493815), a chromogenic substrate that changes colour in the presence of β-lactamases and penicillin-binding proteins.
Chemical Properties	A clear yellow to dark brown liquid. Insoluble in water and denser than water. Corrosive to skin, and eyes. Vapors severely irritate respiratory tract.
Uses	2-Thiopheneacetyl chloride was used in the synthesis of (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, nipecotate-containing immunopotentiator, 5-fluorouracil-cephalosporin prodrug, series of new N,N?-di(thiopheneacetyl)diamines derivatives and 6-β-(thiophen-2?-yl)acetamidomorphine. Also used in the synthesis of Nitrocefin.
Air & Water Reactions	Insoluble in water. Decomposes exothermically in water yielding fumes of toxic hydrogen chloride.
Fire Hazard	Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Consumer Uses	ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

InChI:InChI=1/C6H5ClOS/c7-6(8)4-5-2-1-3-9-5/h1-3H,4H2

39098-97-0 Relevant articles

Intramolecular carbenoid insertions into thiophene: Reactions of 1-diazo-3-(2-thienyl)-2-propanone and 1-diazo-3-(3-thienyl)-2-propanone

Frampton, Christopher S.,Pole, David L.,Yong, Kelvin,Capretta, Alfredo

, p. 5081 - 5084 (1997)

Treatment of 1-diazo-3-(2-thienyl)-2-pro...

Method for efficiently preparing thiophene medical intermediates

-

Paragraph 0014-0019, (2021/05/29)

The invention belongs to the field of sy...

A Simple and Efficient Synthesis of Fused Benzo[ b ]thiophene Derivatives

Ulyankin, Evgeny B.,Kostyuchenko, Anastasia S.,Chernenko, Sergey A.,Bystrushkin, Mikhail O.,Samsonenko, Anna L.,Shatsauskas, Anton L.,Fisyuk, Alexander S.

, p. 2422 - 2434 (2021/04/21)

A new approach to the synthesis of fused...

Lead‐selective membrane electrodes based on dithiophenediazacrown ether derivatives

Xinhao Yang, Naresh Kumar, Hua Chi, D. Brynn Hibbert, Peter W. Alexander

Paragraph 0034; 0038-0041; 0044-0046; 0049-0051; 0054-0056, (2020/08/30)

Three double-armed diazacrown ethers with two thiophene side groups, 7,16-dithenyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (DTDC), 7,16-dithenoyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (DTODC), and 7,16-di-(2-thiopheneacetyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (DTAODC), have been synthesized and used as novel neutral lead(II) ionophores in ion selective electrode applications.

One-pot method for the synthesis of 1-aryl-2-aminoalkanol derivatives from the corresponding amides or nitriles

Bobal, Pavel,Otevrel, Jan,Svestka, David

, p. 25029 - 25045 (2020/07/14)

We have identified a novel one-pot metho...

39098-97-0 Process route

: 1918-77-0
Thiophene-2-acetic acid

: 39098-97-0
2-thienylacetic acid chloride

Conditions

Conditions	Yield
With bis(trichloromethyl) carbonate; N,N-dimethyl-formamide; In dichloromethane; at -10 - 0 ℃; for 5h; Temperature; Reagent/catalyst;	94.7%
With phosgene; 4-cyclopentylaminopyridine hydrobromide; In toluene;	92%
With 1-butyl-3-methylimidazolium hydroxide; thionyl chloride; In chloroform; at 10 ℃; for 8h; Reagent/catalyst; Temperature;	89.8%
With phosgene; In 5,5-dimethyl-1,3-cyclohexadiene; Reflux; Green chemistry;	84.96%
With thionyl chloride;
With tetramethyl-α-chloroenamine; In tetrahydrofuran; at 0 - 25 ℃; for 3h;
With 4-methyl-morpholine; trichlorophosphate; In dichloromethane; at 0 ℃; for 0.25h;
With sulfuryl dichloride; at 60 ℃; for 1h;
With thionyl chloride; for 3h; Heating;
With oxalyl dichloride; N,N-dimethyl-formamide;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
With thionyl chloride; In tetrahydrofuran; for 1.5h; Reflux;
With oxalyl dichloride; Reflux;
With thionyl chloride; for 2h; Reflux;
With thionyl chloride; In dichloromethane; at 50 ℃;
With oxalyl dichloride; N,N-dimethyl-formamide; In toluene; at 20 ℃; for 2h;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
With thionyl chloride; In chloroform; at 20 ℃; Inert atmosphere;
With thionyl chloride; In dichloromethane; Inert atmosphere; Reflux;
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 23 ℃; for 2h; Inert atmosphere;
With thionyl chloride; In dichloromethane; at 0 ℃; for 2h; Reflux;
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; for 5h;
With thionyl chloride; N,N-dimethyl-formamide; Inert atmosphere;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.5h;
With thionyl chloride; at 25 ℃; Inert atmosphere;
With thionyl chloride;
With pyridine; thionyl chloride; In dichloromethane; for 1h; Solvent; Reflux;	25.2 g
With sulfuryl dichloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
With thionyl chloride; at 25 ℃; for 0.5h; Inert atmosphere;
With thionyl chloride; N,N-dimethyl-formamide; In 1,2-dichloro-ethane; for 2h;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 6h;
With bis(trichloromethyl) carbonate; N,N-dimethyl-formamide; In tetrachloromethane; at 25 - 50 ℃; for 2h; Temperature;
With thionyl chloride; In benzene; at 20 - 55 ℃; for 2.66667h;

: 1918-77-0
Thiophene-2-acetic acid

7-amino-3-(2-ethoxylalylhydrazono)methyl-3-cephem-4-carboxylic acid: 7-amino-3-(2-ethoxylalylhydrazono)methyl-3-cephem-4-carboxylic acid

: 39098-97-0
2-thienylacetic acid chloride

7-(2-thienylacetamido)-3-(2-ethoxyalylhydrazono)methyl-3-cephem-4-carboxylic acid monohydrate: 7-(2-thienylacetamido)-3-(2-ethoxyalylhydrazono)methyl-3-cephem-4-carboxylic acid monohydrate

Conditions

Conditions	Yield
With thionyl chloride; triethylamine; In chloroform; water; ethyl acetate;	84%

39098-97-0 Upstream products

1918-77-0
Thiophene-2-acetic acid
5271-67-0
2-Thiophenecarbonyl chloride
527-72-0
2-thiophenylcarboxylic acid
72676-21-2
2-diazo-1-(thiophen-2-yl)ethanone

39098-97-0 Downstream products

115996-22-0
N-<2-(3,4-dimethoxyphenyl)ethyl>-2-(2-thienyl)ethanamide
4461-29-4
2-(thiophen-2-yl)acetamide
68304-15-4
(6R)-7c-methoxy-3-[2-(1-methyl-1H-tetrazol-5-yl)-vinyl]-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
36273-84-4
(6R)-3-acetoxymethyl-7c-methyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

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