Trustworthy Manufacturer Supply 755752-82-0 with Cheap Price, Buy Reliable Quality 1H-Indazole-7-carboxylic acid
- Molecular Formula:C9H8N2O2
- Molecular Weight:176.175
- Vapor Pressure:6.24E-05mmHg at 25°C
- Refractive Index:1.648
- Boiling Point:345.2 °C at 760 mmHg
- PKA:11.93±0.40(Predicted)
- Flash Point:162.6 °C
- PSA：54.98000
- Density:1.324 g/cm3
- LogP:1.34950
1H-Indazole-7-carboxylic acid(Cas 755752-82-0) Usage
|
General Description
|
1H-Indazole-7-carboxylic acid is a chemical compound with the molecular formula C9H6N2O2. It is a carboxylic acid derivative of indazole, a heterocyclic compound with a bicyclic structure. 1H-Indazole-7-carboxylic acid has potential pharmaceutical applications, particularly in the field of medicinal chemistry. It is used as a starting material in the synthesis of various bioactive molecules, including potential drug candidates and pharmacological tools. Its unique structure and properties make it a valuable building block for the development of new drug compounds. Additionally, 1H-Indazole-7-carboxylic acid has been studied for its anti-cancer and anti-inflammatory activities, demonstrating its potential for therapeutic applications. Overall, this compound plays an important role in the development of new pharmaceuticals and biologically active molecules.
|
InChI:InChI=1/C9H8N2O2/c1-13-9(12)7-4-2-3-6-5-10-11-8(6)7/h2-5H,1H3,(H,10,11)
755752-82-0 Relevant articles
Indazole ester compound and pharmaceutical application thereof
-
Paragraph 0088-0091, (2021/10/20)
The invention provides an indazole ester...
Azacycle diketone compound and preparation method thereof (by machine translation)
-
Paragraph 0673-0678, (2020/09/12)
The invention provides a azacyclodiketon...
Preparation method of niraparib tosilate monohydrate
-
Paragraph 0050; 0051, (2017/07/21)
The invention discloses a preparation me...
A novel synthetic method for preparing an anticancer medicine Niraparib
-
Page/Page column 9, (2017/08/02)
A novel synthetic method for preparing a...
755752-82-0 Process route
-
- 22223-49-0
methyl 2-amino-3-methylbenzoate
-
- 755752-82-0,952479-65-1
1H-indazole-7-carboxylic acid methyl ester
Conditions
| Conditions |
Yield |
|
methyl 2-amino-3-methylbenzoate; With acetic anhydride; isopentyl nitrite; In chloroform; at -40 - 20 ℃; for 1h;
With potassium acetate; for 24h; Heating / reflux;
|
68% |
|
methyl 2-amino-3-methylbenzoate; With tetrafluoroboric acid; sodium nitrite; In water; at 0 - 20 ℃; for 1h;
With 18-crown-6 ether; potassium acetate; In chloroform; for 1h;
|
47% |
|
With acetic acid; sodium nitrite; at 20 ℃; for 2h;
|
22% |
|
methyl 2-amino-3-methylbenzoate; With tetrafluoroboric acid; sodium nitrite; In water; at 0 ℃; for 1h;
With 18-crown-6 ether; potassium acetate; In chloroform; at 20 ℃; for 1h;
|
2.98 g |
|
methyl 2-amino-3-methylbenzoate; With acetic acid; sodium nitrite; In water; at 0 - 20 ℃;
With ammonia; water;
|
|
|
Multi-step reaction with 2 steps
1: chloroform / 1 h / 20 - 40 °C
2: potassium acetate; isopentyl nitrite / chloroform / Heating / reflux
With potassium acetate; isopentyl nitrite; In chloroform;
|
|
-
- 677304-69-7
1H-indazole-7-carboxylic acid
-
- 755752-82-0,952479-65-1
1H-indazole-7-carboxylic acid methyl ester
Conditions
| Conditions |
Yield |
|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
|
90% |
755752-82-0 Upstream products
-
22223-49-0
methyl 2-amino-3-methylbenzoate
-
37619-23-1
2-acetylamino-3-methyl-benzoic acid methyl ester
-
95-53-4
o-toluidine
-
1132-03-2
2-(hydroxyimino)-N-(2-methylphenyl)acetamide
755752-82-0 Downstream products
-
677304-69-7
1H-indazole-7-carboxylic acid
-
1092961-09-5
(1H-indazol-7-yl)methanol
-
312746-72-8
1-H-indazole-7-carbaldehyde
-
944899-03-0
3-iodo-1H-indazole-7-carbaldehyde
English
